rTG Fish Oil vs Triglyceride Fish Oil
How rTG fish oil and triglyceride fish oil differ in potency, absorption, tolerance, and cost.
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Side by Side
| Re-esterified Triglyceride Fish Oil | Natural Triglyceride Fish Oil | |
|---|---|---|
| Absorption | High | High |
| How it is absorbed | Concentrated as ethyl esters, then enzymatically converted back to triglycerides. Produced higher plasma EPA+DHA than ethyl esters in a comparative trial (Dyerberg 2010). | EPA and DHA on a glycerol backbone, the form found in fish. Pancreatic lipase releases free fatty acids and monoglycerides for micellar absorption. |
| Typical dose | 500-2,000 mg EPA+DHA daily | 250-1,000 mg EPA+DHA daily for general use |
| Common uses | concentrated dosing with fewer capsules, people who take fish oil without meals | general cardiovascular nutrition, low fish intake |
| Side effects | Similar to triglyceride oil. | Fishy aftertaste, burping, loose stools at high doses. |
| Cost | Moderate | Low |
| Also called | rTG, re-esterified triglyceride | TG fish oil, natural TG |
When to Choose Re-esterified Triglyceride Fish Oil
Choose rTG fish oil when you want a concentrated dose without depending on a fatty meal for absorption. Combines high concentration with the triglyceride structure.
Re-esterified Triglyceride Fish Oil
Concentrated and well absorbed. The practical choice when you need 1-2 g of EPA plus DHA in two or three softgels.
What to look for: At least 600 mg EPA plus DHA per softgel, a published TOTOX or IFOS certificate, and an expiration date.
Find on iHerb Affiliate linkWhen to Choose Natural Triglyceride Fish Oil
Choose triglyceride fish oil when you need a modest dose and want the native form at low cost. Unconcentrated oil typically holds about 30% EPA+DHA, so doses above 1 g EPA+DHA need many capsules.
Natural Triglyceride Fish Oil
Choose triglyceride fish oil when you need a modest dose and want the native form at low cost.
What to look for: Natural Triglyceride Fish Oil named on the Supplement Facts panel, with the amount per serving stated.
Find on iHerb Affiliate linkProducts on Titrate
The Fish Oil and Omega-3 category in Titrate's index holds 7,169 labels from the NIH Dietary Supplement Label Database, 3,579 of them currently on market, out of 214,745 labels indexed in total. The search page ships the 6,000 most detailed of these.
Supplement Search loads one category at a time. Choose the Fish Oil and Omega-3 tab, then type a form such as "triglyceride" under Must contain, or a form to avoid under Must not contain.
Related
References
NIH Office of Dietary Supplements. Omega-3 Fatty Acids: Fact Sheet for Health Professionals.
Harris WS, von Schacky C. The Omega-3 Index: a new risk factor for death from coronary heart disease? Prev Med. 2004;39(1):212-220.
Dyerberg J, et al. Bioavailability of marine n-3 fatty acid formulations. Prostaglandins Leukot Essent Fatty Acids. 2010;83(3):137-141.
Neubronner J, et al. Enhanced increase of omega-3 index in response to long-term n-3 fatty acid supplementation from triacylglycerides versus ethyl esters. Eur J Clin Nutr. 2011;65(2):247-254.
Albert BB, et al. Fish oil supplements in New Zealand are highly oxidised and do not meet label content of n-3 PUFA. Sci Rep. 2015;5:7928.
Bhatt DL, et al. Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia. N Engl J Med. 2019;380(1):11-22.
Manson JE, et al. Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer. N Engl J Med. 2019;380(1):23-32.
Nicholls SJ, et al. Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk: The STRENGTH Randomized Clinical Trial. JAMA. 2020;324(22):2268-2280.
Gencer B, et al. Effect of Long-Term Marine omega-3 Fatty Acids Supplementation on the Risk of Atrial Fibrillation in Randomized Controlled Trials of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis. Circulation. 2021;144(25):1981-1990.